Endocrine Abstracts

Background: In the first trimester, the foetus is dependent on circulating maternal thyroid hormones for normal brain development. Maintenance of euthyroidism is important throughout pregnancy and maternal hypothyroidism is associated with adverse foetal outcomes.Aim: To audit the management of pregnancies complicated by hypothyroidism in a joint antenatal endocrine clinic in comparison with the UK guidelines from the British Thyroid Association (2006).<...

Glargine is an analogue insulin which has a peakless action profile over approximately 24 hours. As a result it has been shown to reduce the frequency of hypoglycaemia thereby enabling achievement of tight glycaemic control. This is important during pregnancy in order to lower the risk of foetal malformations.Method: 17 women, mean age 28 years, with type 1 Diabetes Mellitus on a basal bolus regimen including Glargine became pregnant between January 2004...